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吉林臺

添加時間:2018-06-11 10:42:03  瀏覽次數:[]

    吉林臺pp彩票平台官网,男,蒙古族,19681113日生,內蒙古赤峰市人?;A獸醫學系獸醫病理學教研室,2017年引進人才,主要承擔家畜病理學課程pp彩票平台官网。主要研究方向為傳染病病理及人畜共患病病原體分子生物學研究。20073月在日本岐阜大學聯合獸醫學研究科獲得獸醫學博士學位之后,先后在日本國的帶広畜產大學,國立感染癥研究所,自治醫科大學等大學和研究機構從事科學研究工作,作為主要成員參與了日本國內重大項目及國際合作項目。目前仍和日方大學和研究機構保持良好的科研合作和學術交流關系。

教育背景

1986.9-1991.7     原內蒙古農牧學院獸醫系 獸醫專業 獲得學士學位

1991.9-1994.7     原內蒙古農牧學院獸醫系 獸醫病理學專業 獲得碩士學位

2002.4-2007.3     日本岐阜大學大學院 獣醫臨床病理學學専攻 獲得博士學位

工作經歷

1994.7-2001.9 內蒙古農業大學 醫病理學教研室     助教?講師

2007.4-2008.3  日本廣畜大學 學研究室 博士后研究

2008.4-2009.3 日本國立感染癥研究所 病毒學第一部    任期制研究

2009.4-2017.4  日本自治醫科大學及日本特殊免疫研究所 研究

2017.5-    內蒙古農業大學醫學院 引進人才

科研項目:

在日本期間作為主要成員參與的項目有下:

1.             關于中國新疆地區家畜住血細胞原蟲感染癥的分子流行病學調查pp彩票平台官网,日本學術振興會研究項目(2005,4-2006,3), 承擔血清抗體檢測及病原體基因檢測。

2.             通過調查日本立克氏體感染癥狀況及早期診斷體系的建立而構建早期預警系統, 日本厚生勞動省科學研究項目(2006,42008,3), 主要承擔病原體基因檢索及特異性診斷方法的開發。

3.             解明立克氏體感染對于畜禽的疾病發生與生產性能的影響以及其特異性診斷方法的研究, 日本學術振興會研究項目(2006,42008,3), 進行血清抗體檢測及病原體基因檢索pp彩票平台官网,特殊診斷制劑的研發。

4.             通過調查日本國內的立克氏體感染癥實況及早期診斷體系的建立而構建早期警報系統, 日本厚生勞動省科學研究項目(2008,42009,3), 承擔血清抗體及病原體基因檢測,快速診斷方法的開發。

5.             關于經口感染型病毒性肝炎(甲肝及戊肝)的防止, 病態解析, 基因多樣性及治療的研究,pp彩票平台官网,日本厚生勞動省科學研究項目(2009,42012,3), 擔任動物戊肝病毒的分離鑒定及細胞培養系統的構建。

6.             關于經口感染型病毒性肝炎(甲肝及戊肝)的防止,病態解析,基因多樣性及治療的研究。日本厚生勞動省科學研究項目(2012,42017,3), 運用細胞培養系統進行了戊肝病毒在細胞內的復制及釋放到細胞外的機制的研究pp彩票平台官网,戊肝病毒抗病毒藥物的篩選及藥物作用機制的研究。

發表論文

1.             Jirintai S, Tanggis B, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H: Rat hepatitis E virus from wild rats (Rattus rattus) can propagate efficiently in human hepatoma cell lines. Virus Res. 185:92-102, 2014

2.             Jirintai S, Jinshan, Tanggis, Manglai D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H: Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells. Virus Res. 170 (1-2):126-37, 2012.

3.             Jilintai, Seino N, Hayakawa D, Suzuki M, Hata H, Kondo S, Matsumoto K, Yokoyama N, Inokuma H: Molecular survey for Anaplasma bovis and Anaplasma phagocytophilum infection in cattle in a pastureland where sika deer appear in Hokkaido, Japan. Jpn J Infect Dis. 62:73-75, 2009.

4.             Jilintai, Seino N, Matsumoto K, Hayakawa D, Suzuki M, Hata H, Kondo S, Yokoyama N, Inokuma H: Serological and molecular survey of rickettsial infection in cattle and sika deer in a pastureland in Hidaka District, Hokkaido, Japan. Jpn J Infect Dis. 61:315-317, 2008.

5.             Jilintai, Hashiyama S, Gonda Y, Ishikawa H, Sato M, Miyahara K: Radiographic evaluation of caudal vena cava size as a useful parameter for the diagnosis of heart disease in dairy cattle. J Vet Med Sci. 68:995-998, 2006.

6.             Jinshan, Jirintai, Manglai D, Takahashi M, Nagashima S, Okamoto H: Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia, China. Arch Virol. 155:1217-1226, 2010.

7.             Tanggis, Kobayashi T, Takahashi M, Jirintai S, Nishizawa T, Nagashima S, Nishiyama T, Kunita S, Hayama E, Tanaka T, Mulyanto, Okamoto H. An analysis of two open reading frames (ORF3 and ORF4) of rat hepatitis E virus genome using its infectious cDNA clones with mutations in ORF3 or ORF4. Virus Res. 2018 Apr 2; 249:16-30.

8.             Primadharsini PP, Mulyanto, Wibawa IDN, Anggoro J, Nishizawa T, Takahashi M, Jirintai S, Okamoto H. The identification and characterization of novel rat hepatitis E virus strains in Bali and Sumbawa, Indonesia. Arch Virol. 2018 May;163(5):1345-1349

9.             Primadharsini PP, Miyake M, Kunita S, Nishizawa T, Takahashi M, Nagashima S, Tanggis, Ohnishi H, Kobayashi T, Nishiyama T, Jirintai S, Okamoto H. Full-length genome of a novel genotype 3 hepatitis E virus strain obtained from domestic pigs in Japan. Virus Res. 2017 Aug 15; 240:147-153.

10.         Tsatsralt-Od B, Primadharsini PP, Nishizawa T, Ohnishi H, Nagashima S, Takahashi M, Jirintai S, Nyamkhuu D, Okamoto H. Distinct changing profiles of hepatitis A and E virus infection among patients with acute hepatitis in Mongolia: The first report of the full genome sequence of a novel genotype 1 hepatitis E virus strain. J Med Virol. 2018 Jan;90(1):84-92.

11.         Takahashi M, Kobayashi T, Tanggis, Jirintai S, Mulyanto, Nagashima S, Nishizawa T, Kunita S, Okamoto H. Production of monoclonal antibodies against the ORF3 protein of rat hepatitis E virus (HEV) and demonstration of the incorporation of the ORF3 protein into enveloped rat HEV particles. Arch Virol. 161(12):3391-3404, 2016.

12.         Nagashima S, Kobayashi T, Tanaka T, Tanggis, Jirintai S, Takahashi M, Nishizawa T, Okamoto H. Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone. Virus Res. 223:170-180,2016.

13.         Kobayashi T, Takahashi M, Tanggis, Mulyanto, Jirintai S, Nagashima S, Nishizawa T, Okamoto H.Characterization and epitope mapping of monoclonal antibodies raised against rat hepatitis E virus capsid protein: An evaluation of their neutralizing activity in a cell culture system. J Virol Methods. 233:78-88,2016.

14.         Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Tom Kouki, Takashi Yashiro, Nishizawa T, Okamoto H: Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies. J Gen Virol. 95: 2166-2175, 2014.

15.         Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Kawakami M, Sonoda Y, Suzuki T, Yamamoto S, Shigemoto K, Ashida K, Sato Y, Okamoto H: Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains. Virus Res. 180:59-69, 2014.

16.         Mulyanto, Jodeph BS, I Gusti ASA, Khalid, Takahashi M, Ohnishi H, Jirintai S, Nagashima S, Nishizawa T, Okamoto H: Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis. Virus Res. 179:102-112, 2014.

17.         Nagashima S, Takahashi M, Jirintai S, Tanggis B, Kobayashi T, Nishizawa T, Okamoto H: The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2. Arch Virol. 159 (5):979-991, 2014.

18.         Mulyanto, Depamede SN, Sriasih M, Takahashi M, Nagashima S, Jirintai S, Nishizawa T, Okamoto H: Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia. Arch Virol. 158(1):87-96, 2012.

19.         Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Mizuo H, Yazaki Y, Okamoto H: A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food. Arch Virol. 157:235-246, 2012.

20.         Mulyanto, Pancawardani P, Depamede SN, Wahyono A, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Okamoto H: Identification of four novel subgenotypes (C13-C16) and two inter-genotypic recombinants (C12/G and C13/B3) of hepatitis B virus in Papua Province, Indonesia. Virus Res. 163:129-140, 2012.

21.         Nagashima S, Takahashi M, Jirintai S, Tanaka T, Nishizawa T, Yasuda J, Okamoto H: Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions. J Gen Virol. 92:2838-2848, 2011.

22.         Nagashima S, Takahashi M, Jirintai, Tanaka T, Yamada K, Nishizawa T, Okamoto H: A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells. J Gen Virol. 92:269-278, 2011.

23.         Mulyanto, Depamede SN, Wahyono A, Jirintai, Nagashima S, Takahashi M, Okamoto H: Analysis of the Full-Length Genomes of Novel Hepatitis B Virus Subgenotypes C11 and C12 in Papua, Indonesia. J Gen Virol. 83:54-64, 2011.

24.         Takahashi M, Nishizawa T, Sato H, Sato Y, Jirintai, Nagashima S, Okamoto H: Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype. J Gen Virol. 92:902-908, 2011.

25.         Yokoyama K, Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Yotsumoto S, Okamoto H, Momoi MY: Identification and characterization of a natural inter-genotypic (2b/1b) recombinant hepatitis C virus in Japan. Arch Virol. 156:1591-1601, 2011.

26.         Sato Y, Sato H, Naka K, Furuya S, Tsukiji H, Kitagawa K, Sonoda Y, Usui T, Sakamoto H, Yoshino S, Shimizu Y, Takahashi M, Nagashima S, Jirintai, Nishizawa T, Okamoto H: A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes. Arch Virol. 156:1345-1358, 2011.

27.         Takahashi M, Tanaka T, Takahashi H, Hoshino Y, Nagashima S, Jirintai, Mizuo H, Yazaki Y, Takagi T, Azuma M, Kusano E, Isoda N, Sugano K, Okamoto H: Hepatitis E Virus (HEV) Strains in Serum Samples Can Replicate Efficiently in Cultured Cells Despite the Coexistence of HEV Antibodies: Characterization of HEV Virions in Blood Circulation. J Clin Microbiol. 48:1112-1125, 2010.

28.         Mulyanto, Depamede SN, Surayah K, Tjahyono AAH, Jirintai, Nagashima S, Takahashi M, Okamoto H: Identification and characterization of novel hepatitis B virus subgenotype C10 in Nusa Tenggara, Indonesia. Arch Virol. 155:705-715, 2010.

29.         Ichiyama K, Yamada K, Tanaka T, Nagashima S, Jirintai, Takahashi M, Okamoto H: Determination of the 5'-terminal sequence of subgenomic RNA of hepatitis E virus strains in cultured cells. Arch Virol. 154:1945-1951, 2009.

30.         Chahan B, Jian Z, Jilintai, Miyahara K, Tanabe S, Xuan X, Sato Y, Moritomo T, Nogami S, Mikami T, Maruyama S, Inokuma H: Detection of DNA closely related to 'Candidatus Rickettsia principis' in Haemaphysalis danieli recovered from cattle in Xinjiang Uygur Autonomous Region Area, China. Vet Parasitol. 144:184-187, 2007.

31.         Inokuma H, Ohashi M, Jilintai, Tanabe S, Miyahara K: Prevalence of tick-borne Rickettsia and Ehrlichia in Ixodes persulcatus and Ixodes ovatus in Tokachi district, Eastern Hokkaido, Japan. J Vet Med Sci. 69:661-664, 2007.

32.         Tabuchi M, Jilintai, Sakata Y, Miyazaki N, Inokuma H: Serological survey of Rickettsia japonica infection in dogs and cats in Japan. Clin Vaccine Immunol. 14:1526-1528, 2007.

33.         豬熊壽,吉林臺pp彩票平台官网,下田 崇,富樫義彥,古林與志安,古岡秀文,佐藤基佳,石井三都夫: 右心房內に血栓を認めた後大靜脈血栓癥の育成牛の1癥例.日本獣醫師會雑誌.62(5)376-378, 2009.

34.         山川和宏,杉粼義一,吉林臺,古林與志安,古岡秀文,佐々木直樹,石井三都夫pp彩票平台官网,豬熊 壽: 片側性胸水と血様心嚢水貯留を認めた乳牛の1癥例.日本獣醫師會雑誌. 62(1):49-51, 2008.

35.         青木大介,滄木孝弘,下田崇,富樫義彥pp彩票平台官网,風間武彥,吉林臺pp彩票平台官网,宮原和郎pp彩票平台官网,古林與志安pp彩票平台官网,古岡秀文,松井高峯,佐々木直樹,石井三都夫pp彩票平台官网,豬熊壽: 分娩後5カ月以上経過して癥狀を発現した心室中隔欠損(VSD)の乳牛の2. 北海道獣醫師會雑誌. 52 (6): 219-221, 2008.

36.         趙振華, 李向宇, 關平原, 日穆德瑪, 趙心力, 顧玉芳, 吉仁泰, 王鳳龍, 馬學恩, 吳鐘靈, 成子強. 禽腦脊髓炎油乳劑滅活疫苗的研究. 中國預防獸醫學報, 22(S1), 160-162, 2000.

37.         趙振華,顧玉芳,李潤清,趙心力, 郝俊峰, 吉林臺, 王鳳龍, 馬學恩. 禽腦脊髓炎發病機理的研究. 中國畜禽傳染病. 82(3): 42-48, 1995.

38.         趙振華pp彩票平台官网,林曦pp彩票平台官网,禹旺盛,郝先譜,顧玉芳pp彩票平台官网,馬學恩pp彩票平台官网,李潤清,趙心力,王鳳龍,吉仁泰.禽腦脊髓炎的病理學研究. 中國獸醫雜志. 21(3):5-7, 1995.

39.         趙心力,郭金貴, 馬學恩,李潤清, 吉仁泰, 趙振華, 斯琴,那日蘇. 禽腦脊髓炎瓊脂擴散沉淀抗原制備與應用的研究. 中國畜禽傳染病. 中國獸醫科技. 25(2): 6-8, 1995.

40.         趙心力,趙振華pp彩票平台官网,馬學恩,吉仁泰pp彩票平台官网,顧玉芳,王鳳龍,李潤清. 禽腦脊髓炎病毒的分離與鑒定. 中國畜禽傳染病. 81(2):3-7, 1995.

聯系方式:jirintais@imau.edu.cn;  jirintai@hotmail.com

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